What is alendronate?
Alendronate is a bone resorption inhibitor used to treat high levels of calcium in the blood in cats and dogs. It may also be used as part of the treatment plan for some types of bone cancer. It has been used to treat feline odontoclastic resorptive lesions (FORLs or tooth resorption) in cats.
It is used off label (extra label) in veterinary medicine. Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions carefully, as they may be significantly different from those on the label.
How do I give my pet alendronate?
- Alendronate comes in tablet and liquid suspension forms.
- All forms are given orally (by mouth).
- Give your pet this medication without food, on an empty stomach.
- Do not offer food for at least 30 minutes after dosing. Small amounts of water after giving the medication are fine.
- Measure liquid forms carefully.
- Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears that your pet is feeling better.
This medication should take effect within a few days, though effects may not be noticeable.
What if I miss giving my pet the medication?
If you miss a dose, give it as soon as you remember, and then wait the recommended time for the next dose, as prescribed by your veterinarian. Do not give the pet two doses at once or give extra doses.
Are there any potential side effects?
Alendronate may cause the following side effects:
- Vomiting
- Lack of appetite
Serious adverse reactions may occur. If any of the following signs develop, stop giving alendronate and contact your veterinarian immediately:
- An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face
- Sores or ulcers in the mouth or throat, pain (particularly bone and jaw pain), excessive drooling
Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment and notify your veterinarian if you have any concerns.
Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This long-acting medication should last several weeks, though effects can last longer in pets with kidney or liver disease.
Are there any risk factors for this medication?
DO NOT USE alendronate in:
- Pets that are allergic to any component of the medication
- Pets with severe kidney disease
USE WITH CAUTION in:
- Pets that have trouble swallowing
- Pets that have problems with their esophagus or throat
Are there any drug interactions I should be aware of?
Certain medications should be USED WITH CAUTION when given with alendronate, including:
- Aspirin
- Aminoglycosides
- Diuretics (e.g., furosemide)
- Estrogens (e.g., diethylstilbestrol)
- Famotidine, ranitidine
- NSAIDs (e.g., carprofen, meloxicam)
- Omeprazole and other proton-pump inhibitors
- Oral calcium, magnesium, aluminum
Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.
Is any monitoring needed with this medication?
- Your veterinarian may recommend bloodwork to check blood calcium levels.
- Your veterinarian will let you know when and how they want to reassess your pet to ensure the medication is working and not causing side effects.
- At home, monitor for any side effects such as those noted above. If any occur, stop using the medication and contact your veterinarian.
How do I store alendronate?
- Store at room temperature of 68°F to 77°F (20°C to 25°C).
- Do not freeze.
- Keep medication out of reach of children and pets.
What should I do in case of emergency?
If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms. Adverse effects should be reported to the FDA or Health Canada.
