Erythromycin Ophthalmic

By Lauren R. Forsythe, PharmD, MBA, DICVP; Kayla Hyland, DVM

What is erythromycin ophthalmic?

Erythromycin ophthalmic is an antimicrobial medication used to treat certain types of bacterial eye infections in cats, dogs, and other species. Its use in veterinary medicine is considered off label (extra label). Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions carefully, as they may be significantly different from those on the label.

How do I give my pet erythromycin ophthalmic?

  • Erythromycin ophthalmic comes in an ointment form.
  • Ointments are given topically directly into the eye.
  • Wash your hands before giving your pet this medication.
  • Do not allow the container tip to touch your animal’s eye or any other surface to prevent contamination.
  • If you are administering more than one eye medication to your pet, wait 5 to 10 minutes between each medication. Give eye drops before eye ointments.
  • Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears that your pet is feeling better.

What if I miss giving my pet the medication?

If you miss a dose, give it as soon as you remember, and then continue with the regular dosing schedule. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not give two doses at once.

Are there any potential side effects from erythromycin ophthalmic?

Erythromycin ophthalmic may cause the following side effects:

  • Irritation, stinging, swelling, or itching
  • Reddening in and around the eye

Serious adverse reactions may occur. If any of the following signs develop, stop giving erythromycin ophthalmic and contact your veterinarian immediately:

  • An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face
  • Diarrhea if ingested by pocket pets (e.g., rabbits, guinea pigs, chinchillas, hamsters)

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment and notify your veterinarian if you have any concerns.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting medication should stop working within 24 hours.

Are there any risk factors for this medication?

DO NOT USE erythromycin ophthalmic in:

  • Animals that are allergic to any component.

USE WITH CAUTION in:

  • Rabbits, guinea pigs, chinchillas, hamsters, and other pocket pets, as fatal diarrhea can occur if ingested orally.

Are there any drug interactions I should be aware of?

There are no documented drug interactions for this medication. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

  • In small mammals (i.e., pocket pets), monitor for signs of diarrhea each time this medication is given.
  • Your veterinarian will let you know when and how they want to reassess your pet to ensure the medication is working and not causing side effects.
  • At home, monitor for any side effects such as those noted above. If any occur, stop using the medication and contact your veterinarian.

How do I store erythromycin ophthalmic?

  • Store the medication in its original container, protected from light, at room temperature. Do not freeze.
  • Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms. Report any adverse effects to the FDA or Health Canada.

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