By Rania Gollakner, BS, DVM, MPH

What is grapiprant?

Grapiprant (brand name: Galliprant®) is a non-steroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis pain and inflammation in dogs.

How is grapiprant given?

Grapiprant is given by mouth in the form of a tablet. It can be given with or without food; however, absorption is best on an empty stomach. If vomiting occurs when given on an empty stomach, give the next dose with food or a treat.

This medication will take effect quickly, in about 1 to 2 hours, and improvement in clinical signs should follow.

What if I miss giving my pet the medication?

If you miss a dose, give it when you remember, but if it is close to the time for the next dose, skip the dose you missed and give it at the next scheduled time, and return to the regular dosing schedule. Never give your pet two doses at once or give extra doses.

Are there any potential side effects?

Side effects include vomiting, diarrhea, low appetite, blood or mucous in the stool, and decreases in blood protein levels. This moderate-acting medication should stop working in a few days, although effects can be longer in pets with liver or kidney disease.

Are there any risk factors for this medication?

Grapiprant should not be used in dogs that are allergic to it. It should not be used in dogs that are younger than 9 months old or weigh less than 8 pounds, in breeding, pregnant, or nursing dogs, or in dogs with severe heart disease, as the safe use in these groups have not been established. Grapitrant should be used with caution in dogs that have a history of a sulfonamide drug allergy.

Are there any drug interactions I should be aware of?

The following medications should be used with caution when given with grapiprant: other NSAIDs or corticosteroids, as safety has not yet been established.

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking.

Is there any monitoring that needs to be done with this medication?

Monitor your pet for changes in appetite or for vomiting and diarrhea. Your veterinarian may monitor your pet to be sure that the medication is working.

How do I store grapiprant?

Grapiprant should be stored at room temperature below 30°C (86°F) and protected from light.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.