Imidacloprid + Permethrin + Pyriproxyfen

What is imidacloprid + permethrin + pyriproxyfen?

Imidacloprid + permethrin + pyriproxyfen (brand names K9 Advantix®II, Provecta® Advanced, Activate®II) is a topical (spot-on) antiparasitic drug used in the prevention and treatment of fleas, ticks, mosquitoes, biting flies, and chewing lice in dogs and puppies that are at least 7 weeks of age and weigh at least 4 lb (1.82 kg).

This medication is labeled for use in dogs only. Do not confuse this medication with Advantage®II, or Provecta®II, which are similar products labeled for use in cats and dogs, that do not contain permethrin.

How do I give my pet imidacloprid + permethrin + pyriproxyfen?

• Imidacloprid + permethrin + pyriproxyfen comes in topical solution form.
• Topical solutions are applied directly onto the skin. Part the fur at the base of the head and apply the product directly to visible skin, according to manufacturer instructions. Do not apply to broken skin or wet fur.
• Do not allow animals to lick or groom the application site for several days after application.
• Do not allow this medication to touch the eyes or mouth.
• Cats should be separated and avoid all contact with treated dogs for at least 24 hours after application. 
• Avoid using this medication in households with cats, if possible.
• Humans should avoid direct contact with the application site for 24 hours after this medication is applied.

This medication will take effect quickly and the effects will last several weeks.

What if I miss giving my pet the medication?

If you miss a dose, give it as soon as you remember, and then wait the recommended time for the next dose, as prescribed by your veterinarian. Do not give the pet two doses at once.

Are there any potential side effects?

 Imidacloprid + permethrin + pyriproxyfen may cause the following side effects:

• Redness, itching, or irritation at site of application
• Drooling if ingested

Serious adverse reactions may occur. If any of the following signs develop, stop giving imidacloprid + permethrin + pyriproxyfen and contact your veterinarian immediately:

• An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment and notify your veterinarian if you have any concerns. Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This long-acting medication lasts for several weeks, although effects can be longer in pets with liver or kidney disease.

Are there any risk factors for this medication?

DO NOT USE imidacloprid + permethrin + pyriproxyfen in:

• Cats (permethrin is toxic to cats and any exposure may be fatal)
• Animals that are allergic to any component
• Animals less than the labeled age and weight ranges

USE WITH CAUTION in:

• Pets that are sick or weak
• Pets that are pregnant, nursing, or used for breeding
• Pets that are taking other flea and tick preventives 
• Areas where there are other household animals (e.g., ferrets, rabbits)

Are there any drug interactions I should be aware of?

Certain medications should be USED WITH CAUTION when given with imidacloprid + permethrin + pyriproxyfen, including:

• Other medications used for flea and tick prevention

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

• Your veterinarian will let you know when and how they want to reassess your pet to ensure the medication is working and not causing side effects.
• At home, monitor for any side effects such as those noted above. If any occur, stop using the medication and contact your veterinarian.

How do I store imidacloprid + permethrin + pyriproxyfen?

• Store at room temperature in a cool, dry place.
• Protect from freezing.
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms. Report any adverse effects to the FDA or Health Canada.