What is polyethylene glycol 3350?
Polyethylene glycol 3350 (PEG 3350) is a laxative that keeps water in the colon to soften stools and increase the frequency of stool production. It may also be used to empty the colon before a procedure, such as a colonoscopy. It is available with or without electrolytes. Its use in cats and dogs is off label (extra label). Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions carefully, as they may be significantly different from those on the label.
How do I give my pet PEG 3350?
- PEG 3350 is given by mouth, in the form of a powder or liquid. Measure the liquid form carefully.
- It may be mixed with food but ensure your pet swallows the entire dose.
- Make sure your pet always has access to plenty of clean drinking water while using this medication.
- Contact your veterinarian if you have trouble administering it.
This medication can take effect 1 hour after administration.
What if I miss giving my pet the medication?
If you miss a dose, give it as soon as you remember, and then continue with the regular dosing schedule. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once or give extra doses.
Are there any potential side effects?
PEG 3350 may cause the following side effects:
- Vomiting
- Diarrhea
- Nausea
- Flatulence
- Abdominal cramping
If any of these signs persist, worsen, or are severe, contact your veterinarian. Using PEG 3350 with electrolytes can cause fluid and electrolyte imbalances, so follow your veterinarian’s directions carefully to avoid overdosing or using it for too long.
Drug sensitivities can develop over time, with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment and notify your veterinarian if you have any concerns. Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting medication should stop working within 24 hours.
Are there any risk factors for this medication?
DO NOT USE PEG 3350 in:
- Pets that are allergic to it
- Pets with intestinal blockage/obstruction
- Pets with toxic colitis or gastric retention
PEG 3350 with electrolytes should be USED WITH CAUTION in:
- Pets with inflammatory bowel disease
- Pets with fluid/electrolyte imbalances
- Pets that are pregnant or lactating
Are there any drug interactions I should be aware of?
Several medications should be used with caution when given with PEG 3350, including:
- Diuretics
- Extended-release oral medications
- Opioids
- Other laxatives
- Tricyclic antidepressants
Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) your pet is taking before starting any treatment.
Is any monitoring needed with this medication?
- When using PEG 3350 with electrolytes, fluid and electrolyte status must be monitored.
- When using PEG 3350 without electrolytes, monitor your pet’s bowel movements and consult your veterinarian about dosing to achieve the recommended bowel movement frequency and consistency.
- Your veterinarian may recommend regular checkups and laboratory testing, depending on your pet’s condition.
- At home, monitor for any side effects such as those noted above. If any occur, stop using the medication and contact your veterinarian.
How do I store PEG 3350?
- Store PEG 3350 powder at 77°F (25°C) or as the label directs, in a tight container, and protected from heat and light.
- Store liquid solutions of PEG 3350 in the refrigerator and use within the directed interval.
- Do not freeze this medication.
- Keep the container out of reach of children and pets.
What should I do in case of an emergency?
Call your veterinary office immediately if you suspect an overdose or an adverse reaction to the medication. If they are unavailable, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms.
