What is praziquantel/pyrantel pamoate?
Praziquantel/pyrantel pamoate (brand name Drontal®) is an oral antiparasitic drug used to treat and control hookworms, roundworms, and tapeworms in cats and kittens that are at least 8 weeks of age and weigh at least 0.9 kg (2 lb), and in dogs and puppies that are at least 12 weeks of age and weigh at least 2.7 kg (6 lb).
It is used “off label” or “extra label” in exotic species. Many drugs are commonly prescribed for off-label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions carefully.
Do not confuse this medication with Drontal® Plus, a similar medication that contains febantel and is labeled for use in dogs only.
How do I give my pet praziquantel/pyrantel pamoate?
Praziquantel/pyrantel pamoate comes in tablet form.
- Tablets are given orally (by mouth).
- This medication may be given with food or on an empty stomach.
- Watch your pet for a few minutes after giving the medication to make sure the entire tablet is swallowed.
This medication will take effect in about 1 to 2 hours.
What if I miss giving my pet the medication?
Give the missed dose as soon as you remember and then wait the recommended time for the next dose, as prescribed by your veterinarian. Do not give the pet two doses at once.
Are there any potential side effects from praziquantel/pyrantel pamoate?
Praziquantel/pyrantel pamoate may cause the following side effects:
- loss of appetite, vomiting, diarrhea
- lack of energy or coordination, stumbling, weakness
- drooling in cats
The following reactions are rare, but if they occur, contact your veterinarian immediately:
- an allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face
Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.
Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This moderate-acting medication should stop working within a few days, although effects can be longer in pets with liver or kidney disease.
Are there any risk factors for this medication?
This medication should be AVOIDED in:
- animals allergic to any component
- kittens less than 8 weeks old and weighing less than 2 lb
- puppies less than 12 weeks old and weighing less than 6 lb
This medication should be used with CAUTION in pets who are:
- sick or weak
- pregnant or nursing
- used for breeding
Are there any drug interactions I should be aware of?
Certain medications should be USED WITH CAUTION when given with praziquantel/pyrantel pamoate, including:
- albendazole
- cimetidine
- CYP34A inducers (e.g., dexamethasone, phenobarbital)
- CYP34A inhibitors (e.g., itraconazole, ketoconazole)
Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.
Is any monitoring needed with this medication?
Your veterinarian may schedule follow-up visits for monitoring. In this case, follow your veterinarian’s directions.
How do I store praziquantel/pyrantel pamoate?
- Store at room temperature.
- Protect from light and moisture.
- Keep medication out of reach of children and pets.
What should I do in case of emergency?
If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.
