Triple Antibiotic Ophthalmic with Hydrocortisone (Neomycin, Polymyxin B, Bacitracin, Hydrocortisone)

By Kayla Hyland, DVM

What is triple antibiotic ophthalmic with hydrocortisone?

Triple antibiotic ophthalmic with hydrocortisone, also known as neomycin and polymyxin B with bacitracin and hydrocortisone (brand names Trioptic-S®, Vetropolycin®) is a combination antimicrobial medication with a steroid (hydrocortisone) used to treat certain types of bacterial infections. It is used to treat eye infections and inflammation surrounding the eye in cats, dogs, and other animals.

It may be used “off label” or “extra label” for allergic eye conditions in animals. Many drugs are commonly prescribed for off-label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions carefully.

How do I give my pet triple antibiotic ophthalmic with hydrocortisone?

Triple antibiotic ophthalmic with hydrocortisone comes in ointment and liquid drop suspension forms.

  • Ointments and liquids are given topically directly into the eye. 
  • Wash your hands before giving your pet this medication.
  • Do not allow the dropper tip to touch your animal’s eye or any other surface to prevent contamination.
  • If you are administering more than one eye medication to your pet, wait 5 to 10 minutes between each medication. Give eye drops before eye ointments.
  • Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears that your pet is feeling better.

What if I miss giving my pet the medication?

If you miss a dose, give it as soon as you remember, and then continue with the regular dosing schedule. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once.

Are there any potential side effects from triple antibiotic with hydrocortisone?

Triple antibiotic with hydrocortisone may cause the following side effects:

  • irritation, swelling, reddening, or itchiness
  • drooping of the eyelid

The following reactions are rare in dogs but occur more frequently in cats; if they occur, contact your veterinarian immediately:

  • an allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting medication should stop working within 24 hours.

Are there any risk factors for this medication?

This medication should NOT BE USED in:

  • animals allergic to any component
  • birds, if viral or fungal infection suspected, or if an eye ulcer is present

This medication should be USED WITH CAUTION in:

  • cats, as allergic reactions to the neomycin and polymyxin B components have been documented
  • animals with diabetes and/or glaucoma
  • and animals who are pregnant or nursing

Are there any drug interactions I should be aware of?

No known drug interactions have been reported for this medication. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

  • Your veterinarian may schedule a follow-up visit for after the course of medication is complete to ensure the infection has been cleared and/or do additional testing to ensure this is the right medication for the type of infection present. In this case, follow your veterinarian’s directions.
  • In cats, monitor closely for signs of allergic reaction each time this medication is administered.
  • In diabetic animals, monitor for signs of changes in blood sugar level and/or changes in urination.

How do I store triple antibiotic ophthalmic with hydrocortisone ointment?

  • Store the medication in its original container, protected from light, at room temperature. 
  • If your veterinarian or pharmacist has made a special (compounded) formulation for your pet, follow the storage recommendations and expiration date for the product.
  • Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

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