What is buprenorphine long-acting transdermal?
Buprenorphine long-acting transdermal (brand name Zorbium®) is an opioid analgesic (pain relieving) medication. It is labeled for use in treating post-surgery pain in cats. This medication is a controlled narcotic available for use in the United States. There is no Health Canada-approved equivalent.
It may be used off label (extra label) to treat other types of pain in cats and to treat pain in other species. Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions carefully, as they may be significantly different from those on the label.
How is buprenorphine long-acting transdermal given to my pet?
- Buprenorphine long-acting transdermal comes in liquid transdermal form (absorbed through the skin).
- The liquid is applied topically, directly onto the skin.
- This medication is administered once, before surgery, by your veterinary team. There is no repeat dosing at home.
This medication will take effect quickly, in about 1 to 2 hours.
Are there any potential side effects?
Buprenorphine long-acting transdermal may cause the following side effects:
- Changes in body temperature or blood pressure
- Changes in heart rate or breathing rate
- Sedation
- Dysphoria
- Hyperactivity
- Reduced appetite
The following reactions are rare, but if they occur, contact your veterinarian immediately:
- An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face
Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment and notify your veterinarian if you have any concerns.
Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This long-acting medication will last up to 4 days, although effects can be longer in pets with liver or kidney disease.
Are there any risk factors for this medication?
DO NOT USE buprenorphine long-acting transdermal in:
- Pets with known allergies to any components or with known sensitivities to opioids
USE WITH CAUTION in:
- Pets with liver disease, kidney disease, respiratory disease, or cardiac disease
- Cats younger than 4 months old
- Cats that weigh less than 1.2 kg (2.6 lb) or more than 7.5 kg (16.5 lb), as safe use in these populations has not been tested
Are there any drug interactions I should be aware of?
Certain medications should be USED WITH CAUTION when given with buprenorphine long-acting transdermal, including:
- Anticonvulsants (e.g., phenobarbital)
- Benzodiazepines, barbiturates, tranquilizers, and other nervous system depressants
- Clomipramine, fluoxetine, mirtazapine, trazadone
- Erythromycin
- Ketoconazole, itraconazole, fluconazole
- Local anesthetics (e.g., lidocaine)
- Metoclopramide
- Other opioids and opioid-like medications (e.g., tramadol)
- Rifampin
Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.
Is any monitoring needed with this medication?
- Your veterinarian may prescribe two different medications, and a drug interaction may be anticipated. In this case, your veterinarian may vary the dose and/or monitor your pet more closely.
- Your veterinarian may schedule follow-up visits for monitoring. In this case, follow your veterinarian’s directions.
How do I store buprenorphine long-acting transdermal?
- Buprenorphine long-acting transdermal is a controlled narcotic and labeled for veterinary team administration only, so it is stored securely at your veterinary clinic.
- Keep medication out of reach of children and pets.
What should I do in case of emergency?
If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet’s weight and symptoms.
