What is selamectin + sarolaner topical?
Selamectin + sarolaner (Revolution Plus®) is used in cats 8 weeks and older to prevent heartworms and intestinal parasites (hookworms and roundworms), kill and prevent flea infestations, and treat tick infestation (Gulf Coast tick, American dog tick, and deer tick). It is also used to treat and control ear mites.
It may also be used off label (extra label) to treat Demodex mites (demodicosis) in cats. Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions carefully, as they may be significantly different from those on the label.
How do I give my pet selamectin + sarolaner?
- Selamectin + sarolaner is applied to the skin on the back of the neck.
- To apply, part the hair and apply the medication directly onto the skin.
- Once the medication is applied to the skin, avoid massaging it into the skin or touching the application site while it is wet.
- Bathe your cat within the first 24 hours of application.
This medication starts to kill fleas in 6 hours and ticks within 24 hours of application.
What if I miss giving a dose to my pet?
If you miss a dose, give it as soon as you remember and start a new monthly dosing schedule. For example, if you forgot to give your pet their dose on June 1 and remember on June 18, give the dose on June 18 and start a new monthly schedule. You will give your pet the next dose on July 18. Do not give your pet two doses at once. Contact your veterinarian if you are concerned about a missed dose.
Are there any potential side effects?
Selamectin + sarolaner may cause the following side effects:
- Lethargy
- Vomiting
- Skin lesions
- Diarrhea
- Itching
- Anorexia (no appetite)
- Conjunctivitis
- Sneezing
If your pet ingests selamectin + sarolaner, side effects may include:
- Decreased appetite
- Vomiting
- Soft stool
- Salivation
Sarolaner belongs to a class of drugs called isoxazolines, which have been associated with neurological side effects. If any of the following signs develop, stop giving selamectin + sarolaner and contact your veterinarian immediately:
- Tremors
- Ataxia (wobbly gait)
- Seizures
Drug sensitivities can develop over time, with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment and notify your veterinarian if you have any concerns.
Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This long-acting medication is designed to last for at least four weeks. However, negative side effects are usually short-lived if they occur at all.
Are there any risk factors for this medication?
USE WITH CAUTION in:
- Animals with low body fat (sick or very young), as they are more prone to side effects
- Cats with neurologic conditions, including seizures
- Cats that are breeding, pregnant, or nursing (safety has not been established)
Are there any drug interactions I should be aware of?
There are no documented drug interactions for this medication. Be sure to tell your veterinarian about any medications (including vitamins, supplements, and herbal therapies) that your pet is taking before starting any treatment.
Is any monitoring needed with this medication?
- Your veterinarian may recommend testing your cat for heartworm before starting treatment.
- Your veterinarian may recommend routine heartworm testing to be sure that the medication is working.
- At home, monitor for any side effects such as those noted above. If any occur, stop using the medication and contact your veterinarian.
How do I store this medication?
- Store selamectin + sarolaner in its original packaging at or below 86°F (30°C).
- Keep the container out of reach of children and pets.
What should I do in case of an emergency?
If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms.
